SELECT 
  * 
FROM 
  cscart_bm_layouts 
WHERE 
  1 
  AND cscart_bm_layouts.company_id = 1 
  AND layout_id = 6

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "table_name": "cscart_bm_layouts",
      "access_type": "const",
      "possible_keys": [
        "PRIMARY"
      ],
      "key": "PRIMARY",
      "used_key_parts": [
        "layout_id"
      ],
      "key_length": "4",
      "ref": [
        "const"
      ],
      "rows": 1,
      "filtered": 100
    }
  }
}